'下来' indicates the completion and retention/fixing of an action, or carrying something through to the end; '不下来' indicates inability to retain, record, or endure to the end.
Used in spoken Chinese, equivalent to '干什么' (why / what for), asking for reason or purpose, often with a rhetorical or mildly reproaching tone.
Used colloquially to mean deliberately making things difficult for someone or causing embarrassment; '别跟自己过不去' means 'don't be hard on yourself / don't make yourself miserable'.
Indicates relying or depending on a certain condition, means, or person to sustain life or accomplish a goal.
'上' as a complement indicates achieving a goal, realizing a wish, or attaining a certain status/standard; '不上' means failing to attain the goal or missing out on enjoying it.
Expresses a hypothetical concession (even if... still...), indicating that the conclusion in the second clause still holds true even under extreme hypothetical conditions.
Means 'in addition to what has been mentioned', used to introduce supplementary situations, facts, or reasons.
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